Randomized, Investigator-Blinded Study to Compare the Efficacy and Tolerance of a 650-microsecond, 1064-nm YAG Laser to a 308-nm Excimer Laser for the Treatment of Mild to Moderate Psoriasis Vulgaris

Mark S. Nestor MD PhD,a,b Daniel Fischer DO MS,a David Arnold DOa

Current options for the treatment of psoriasis include systemic and topical modalities. Systemic therapies include immune inhibitors, immune modulators and, for moderate to severe disease, biological agents.1 Primarily, for mild to moderate psoriasis, topical treatments comprise ointments, medicated bath with diastase or herbal extracts, and phototherapy. Phototherapy is safe, effective, and does not incur the side effects of systemic medications.2

The 308-nm excimer laser is considered first-line phototherapy for topical plaque psoriasis.2 The efficacy and safety of this laser has been extensively evaluated for the treatment of psoriasis.3-9 The advantage of the excimer laser is its ability to treat psoriatic lesions with high doses of monochromatic radiation while sparing unaffected skin.2 Three protocols have been developed to optimize treatment: the minimal erythema dose, the induration, and the minimal blistering dose.7

A novel 650-microsecond 1064-nm Nd: YAG laser was introduced in 2009 by Khatri and colleagues who used the laser to remove unwanted hair.10 Since then, other investigators11, 12 have used the 650-microsecond laser to treat skin of color, onychomycosis,13 facial telangiectasias,14 and acne.15 The advantage of the 650-microsecond laser is that treatment does not require cooling or anesthesia because the pulse duration is shorter than or equal to the thermal relaxation time of the therapeutic target. This feature minimizes scarring, pigmentary changes, thermal damage to surrounding tissues, and discomfort during or after treatment.15

The 650-microsecond laser has received FDA approval for the treatment of psoriasis. The primary objective of this study was to compare the ability of the 650-microsecond, 1064-nm pulsed YAG laser (LightPod Neo®, Aerolase Corp., Tarrytown, NY) to clear psoriatic plaques with that of the 308-nm excimer laser (XTRAC Velocity 400®, PhotoMedex, Inc., Montgomeryville, PA). Plaques were located on the limbs of subjects with mild-to-moderate psoriasis vulgaris.

Table of Contents

Hyperpigmentation

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Photos Courtesy of Jennifer Parker-Porter, MD.

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Vascular Lesions

Photos Courtesy of Dr. Guilia Kasimova.

Photos Courtesy of Michael Gold, MD.

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Rosacea / Redness

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Photos Courtesy of Dr. Nabil Fakih.

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Hair Removal

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PFB

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Photos Courtesy of Wendy Roberts, MD.

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Scars

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Photos Courtesy of Bradley Bloom, MD.

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Autoimmune Disorders

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Photos Courtesy of Dr. Sakhiya.

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Skin Rejuvenation

Photos Courtesy of Catie Cutler, LE.

Photos Courtesy of Chesahna Kindred, MD.

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Acne

Photos Courtesy of Michael Gold, MD.

Photos Courtesy of Michael Gold, MD.

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Staff Accountant / Junior Accountant

Aerolase Corporation, a leading aesthetic laser innovator, seeks a Staff Accountant / Junior Accountant. Having made the Inc. 5000 list as one of the world’s fastest growing private companies as well as annual best-in-class product awards, Aerolase has transformed the market with products that provide uniquely tolerable treatments to the patients and exceptionally high ROI for the practitioners. The company offers competitive and an exciting high-growth company culture.

Staff Accountant / Junior Accountant

• Provide support to the Controller and the management team
• Maintain day-to-day financial accounting functions, including A/P, A/R, expense tracking
• Support the month-end close process, ensuring accurate and timely monthly, quarterly, and year-end financial statements.
• Uploading annual budget and tracking actual to budget variances
• Use of financial reporting software
• Support external auditors and other required outside reporting requirements
• Participation in quarterly inventory reconciliations
• Assist team with projects such as policy creation, system implementation, client support etc.

• Some experience with and strong understanding of the monthly close process and technical accounting
• Detailed oriented, with ability to see the big picture
• Self-starter who can work independently and employ time management skills to meet deadlines.
• Knowledge of MS Excel (V-lookup, formulas, pivot tables).
• Strong interpersonal and communication skills
• Sound judgment and problem-solving skills

• Bachelor’s or master’s degree in Accounting a MUST, good understanding of GAAP
• 1-3 years’ experience in an accounting function (including internship)
• General Ledger/Operational Accounting experience
• Knowledge of Quickbooks or other reporting software a plus (more the better)
• Industry experience a plus

Senior Accountant

Aerolase Corporation, a leading aesthetic laser innovator, seeks a Senior Accountant. Having made the Inc. 5000 list as one of the world’s fastest growing private companies as well as annual best-in-class product awards, Aerolase has transformed the market with products that provide uniquely tolerable treatments to the patients and exceptionally high ROI for the practitioners. The company offers competitive and an exciting high-growth company culture.

Senior Accountant:

• Provide support to the Controller and the management team
• Own day-to-day financial accounting functions, including A/P, A/R, expense tracking
• Assist in establishing and maintaining policies & procedures in accordance with GAAP and Aerolase policy
• Key contributor to the month-end close process, ensuring accurate and timely monthly, quarterly, and year-end financial statements.
• Assist in the preparation of management reports – (cash management, various projections, month end reporting package)
• Involvement with the annual budget process
• Use of financial reporting software
• Support external auditors and other required outside reporting requirements
• Prepare and submit payroll
• Participation in quarterly inventory reconciliation to the perpetual
• Ad hoc projects

• Strong knowledge of the monthly close process and technical accounting

• Detailed oriented, with ability to see the big picture

• Experience in continuous improvement and accounting best practices

• Self-starter who can work independently and employ time management skills to meet deadlines.

• System savvy – ability to learn new financial software

• Intermediate knowledge of MS Excel (V-lookup, formulas, pivot tables).

• Global consolidations experience a plus

• Strong interpersonal and communication skills

• Sound judgment and problem-solving skills

• Bachelor’s or master’s degree in Accounting a MUST, good understanding of GAAP

• 3+ years’ experience working as a staff/senior accountant

• General Ledger/Operational Accounting experience a must

• Extensive knowledge of Quickbooks and other reporting software

• Prior involvement with system implementation

• Prior public accounting experience (any size firm) a plus

• Industry experience a plus

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