650-microsecond 1064nm Nd:YAG laser treatment of acne: A double-blind randomized control study

Journal of Cosmetic Dermatology, July 2020

David J. Goldberg MD, JD; Katarina Kesty MD, MBA; Skin Laser and Surgery Specialists of NY & NJ, Hackensack, NJ, USA

Acne vulgaris is one of the most common conditions treated by dermatologists.1 The pathogenesis of acne is multifactorial. Epidermal hyperproliferation and excess sebum production result in blockage of the pilosebaceous units. This is followed by increased proliferation and activity of commensal skin bacteria Propionibacterium acnes, resulting in subsequent inflammation.2,3 Moderate acne is traditionally treated with topical cleansers, retinoids, and antibiotics. Moderate-to-severe acne may sometimes require additional treatment with systemic antibiotics or retinoids.4 Treatments can often be irritating, unsatisfactory, and the chronic exacerbations and remissions throughout adolescence and adulthood can have a major impact on patient quality of life.5,6 Devices and lasers are often employed as an adjunctive treatment for acne and acne scarring. Common treatments include chemical peels, nonablative radiofrequency, and microneedling with radiofrequency.711 Studies have reported some efficacy of laser treatment.1216 Laser therapy can be successful in diminishing acne vulgaris lesions by halting overactive sebaceous gland activity and alleviating the effects of inflammation. The mechanism of action is thought to be by activation of porphyrins produced by Propionibacterium acnes, resulting in the destruction of cell membranes of these bacteria. Lasers with a 1064 nm wavelength have been studied for acne. One study done by Ballin and Ubelhoer treated one patient with 10 sessions of a laser with 1064-nm Nd:YAG and resulted in almost 100% clearance of lesions.17 Another study compared intense-pulsed light with 1064-nm Nd:YAG and found no significant difference in the treatment of acne.18

Typical Nd:YAG 1064nm lasers operate with longer pulse durations anywhere from 3 to 30 milliseconds. The laser used in this study has a 650-microsecond pulse duration. This is a new technology where all necessary power settings from 4 J/cm2 to 255 J/ cm2 can be delivered within a 650-microsecond pulse in a variety of spot sizes and at a fast repetition rate of up to 2.0 Hz. A total of 650 microseconds is below the thermal relaxation time of the skin tissue, so the skin has time to cool itself between pulses, thus confining the heat in the selectively absorbed target for higher clinical efficacy and safety to the surrounding skin.19 The high-energy pulse is delivered into the target in such a short-pulse duration. The targeted structure has less time to lose heat, through conduction, to the surrounding skin, so the target reaches a higher temperature.

A higher temperature in the targeted tissue translates into greater target tissue destruction for higher efficacy. We undertook a randomized controlled study evaluating the use of 650-microsecond 1064 nm Nd:YAG laser compared with a sham in the treatment of moderate-to-severe acne.

Table of Contents

Hyperpigmentation

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Vascular Lesions

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Rosacea / Redness

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Hair Removal

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PFB

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Scars

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Autoimmune Disorders

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Skin Rejuvenation

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Acne

Photos Courtesy of Michael Gold, MD.

Photos Courtesy of Michael Gold, MD.

Learn more about treating acne today.

Staff Accountant / Junior Accountant

Aerolase Corporation, a leading aesthetic laser innovator, seeks a Staff Accountant / Junior Accountant. Having made the Inc. 5000 list as one of the world’s fastest growing private companies as well as annual best-in-class product awards, Aerolase has transformed the market with products that provide uniquely tolerable treatments to the patients and exceptionally high ROI for the practitioners. The company offers competitive and an exciting high-growth company culture.

Staff Accountant / Junior Accountant

• Provide support to the Controller and the management team
• Maintain day-to-day financial accounting functions, including A/P, A/R, expense tracking
• Support the month-end close process, ensuring accurate and timely monthly, quarterly, and year-end financial statements.
• Uploading annual budget and tracking actual to budget variances
• Use of financial reporting software
• Support external auditors and other required outside reporting requirements
• Participation in quarterly inventory reconciliations
• Assist team with projects such as policy creation, system implementation, client support etc.

• Some experience with and strong understanding of the monthly close process and technical accounting
• Detailed oriented, with ability to see the big picture
• Self-starter who can work independently and employ time management skills to meet deadlines.
• Knowledge of MS Excel (V-lookup, formulas, pivot tables).
• Strong interpersonal and communication skills
• Sound judgment and problem-solving skills

• Bachelor’s or master’s degree in Accounting a MUST, good understanding of GAAP
• 1-3 years’ experience in an accounting function (including internship)
• General Ledger/Operational Accounting experience
• Knowledge of Quickbooks or other reporting software a plus (more the better)
• Industry experience a plus

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Aerolase Corporation, a leading aesthetic laser innovator, seeks a Senior Accountant. Having made the Inc. 5000 list as one of the world’s fastest growing private companies as well as annual best-in-class product awards, Aerolase has transformed the market with products that provide uniquely tolerable treatments to the patients and exceptionally high ROI for the practitioners. The company offers competitive and an exciting high-growth company culture.

Senior Accountant:

• Provide support to the Controller and the management team
• Own day-to-day financial accounting functions, including A/P, A/R, expense tracking
• Assist in establishing and maintaining policies & procedures in accordance with GAAP and Aerolase policy
• Key contributor to the month-end close process, ensuring accurate and timely monthly, quarterly, and year-end financial statements.
• Assist in the preparation of management reports – (cash management, various projections, month end reporting package)
• Involvement with the annual budget process
• Use of financial reporting software
• Support external auditors and other required outside reporting requirements
• Prepare and submit payroll
• Participation in quarterly inventory reconciliation to the perpetual
• Ad hoc projects

• Strong knowledge of the monthly close process and technical accounting

• Detailed oriented, with ability to see the big picture

• Experience in continuous improvement and accounting best practices

• Self-starter who can work independently and employ time management skills to meet deadlines.

• System savvy – ability to learn new financial software

• Intermediate knowledge of MS Excel (V-lookup, formulas, pivot tables).

• Global consolidations experience a plus

• Strong interpersonal and communication skills

• Sound judgment and problem-solving skills

• Bachelor’s or master’s degree in Accounting a MUST, good understanding of GAAP

• 3+ years’ experience working as a staff/senior accountant

• General Ledger/Operational Accounting experience a must

• Extensive knowledge of Quickbooks and other reporting software

• Prior involvement with system implementation

• Prior public accounting experience (any size firm) a plus

• Industry experience a plus

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