Treatment of Moderate to Severe Acne and Post-Acne Scars with a 650-Microsecond 1064nm Laser Combined with Low Dose Isotretinoin

Michael H. Gold, Natalia Manturova Evgenievna, Larisa Kruglova Sergeevna, Evgenia Ikonnikova Vladimirovna

Gold M., Evgenievna N., Sergeevna L., Vladimirovna E., “TREATMENT OF MODERATE TO SEVERE ACNE AND POST ACNE SCARS WITH 650 MICROSECOND 1064 nm LASER COMBINED WITH LOW DOSE ISOTRETINOIN,” Lasers Surg Med. 2019 Mar;51(S31):S13-14

Background: Research indicates acne therapy using isotretinoin can lead to a delay in the repair of skin integuments (i.e., skin scar tissue), and therefore the use of laser and phototherapy in patients receiving retinoid therapy is relatively contraindicated. Traditionally it is believed that laser procedures should be postponed for at least 6–8 months after the end of systemic therapy with isotretinoin. However, a more current version of treatment protocols and the transition to lower dosages have made it possible to reduce the likelihood of side effects of the combination therapy, which presents a significant development for the treatment of post-acne scars and the prevention of their occurrence.

Study Design/Materials and Method: The study included 28 female (60.8%) and 18 male (39.2%) patients of skin types I–III, aged 18 to 29 years with moderate to severe acne (up to 20 papulopustular elements) complicated by atrophic scars. In all patients included in the study, genetic analysis revealed the polymorphism of the genes Col1A2, MMP3, ESR1, MMP1 MMP7, which can lead to the appearance of scars of this morphotype. IGA parameters before the start of therapy averaged 1.8..