New Webinar: The Neo Derm Effect: A Year of Revenue Growth

الليزر Nd:YAG بمدة نبضة 650 ميكروثانية وطول موجي 1064 نانومتر لعلاج حب الشباب: دراسة ضابطة عشوائية مزدوجة التعمية

مجلة الأمراض الجلدية التجميلية، يوليو 2020 ديفيد جيه. جولدبرج، طبيب، دكتور في القانون كاتارينا كيستي، طبيبة، حاصلة على ماجستير في إدارة الأعمال؛ اختصاصيو الليزر وجراحة الجلد في نيويورك ونيوجيرسي، هاكنساك، نيوجيرسي، الولايات المتحدة الأمريكية

حب الشباب الشائع هو أحد أكثر الحالات شيوعًا التي يعالجها أطباء الجلد. 1 ينشأ حب الشباب عن عوامل متعددة. يؤدي فرط الانتشار الجلدي وزيادة إفراز الدهون إلى انسداد الوحدات الشعرية الزهمية. ويتبع ذلك زيادة انتشار ونشاط بكتيريا الجلد المتعايشة البروبيونية العدية، مما يؤدي إلى التهاب لاحق. 2,3 يتم علاج حب الشباب المتوسط بشكل تقليدي بالمنظفات الموضعية والريتينويدات والمضادات الحيوية. قد يتطلب حب الشباب المتوسط إلى الشديد أحيانًا علاجًا إضافيًا بالمضادات الحيوية الجهازية أو الريتينويدات. 4 يمكن أن تكون العلاجات في كثير من الأحيان مزعجة، وغير مرضية، ويمكن أن يكون للتفاقم المزمن والهدأة بعد ذلك خلال فترة المراهقة والبلوغ تأثير كبير على نوعية حياة المريض. 5,6 غالبًا ما تستخدم الأجهزة والليزر كعلاج مساعد لحب الشباب وندبات حب الشباب. تشمل العلاجات الشائعة التقشير الكيميائي ، وترددات الراديو غير الاستئصالية، والوخز بالإبر الدقيقة مع ترددات الراديو.711 أشارت الدراسات إلى بعض فاعلية العلاج بالليزر.12 16 يمكن أن ينجح العلاج بالليزر في تقليل آفات حب الشباب الشائع عن طريق وقف نشاط الغدد الدهنية مفرطة النشاط وتخفيف آثار الالتهاب. يُعتقد أن آلية العمل تتم عن طريق تنشيط البورفيرينات التي تنتجها بكتيريا البروبيونية العدية، مما يؤدي إلى تدمير أغشية الخلايا لهذه البكتيريا. تمت دراسة الليزر ذي الطول الموجي 1064 نانومتر لعلاج حب الشباب. عالجت إحدى الدراسات التي أجراها بالين وأوبلهوير مريضًا واحدًا بعشر جلسات باستخدام جهاز العلاج بالليزر الذي يعمل بتقنية Nd:YAG بطول موجي يبلغ 1064 نانومتر وأسفرت عن إزالة ما يقرب من 100% من الآفات.17 قارنت دراسة أخرى الضوء النبضي المكثف الذي يعمل بتقنية Nd:YAG بطول موجي يبلغ 1064 نانومتر ولم تجد فرقًا كبيرًا في علاج حب الشباب.18

تعمل أجهزة الليزر النموذجية التي تعمل بتقنية Nd:YAG بطول موجي يبلغ 1064 نانومتر مع فترات نبض أطول في أي مكان من 3 إلى 30 مللي ثانية. وجهاز الليزر المستخدم في هذه الدراسة له نبضة مدتها 650 ميكروثانية. وهذه تقنية جديدة حيث يمكن توصيل جميع إعدادات الطاقة الضرورية من 4 جول/سم2 إلى 255 جول/ سم2 في غضون نبضة تبلغ 650 ميكروثانية في مجموعة متنوعة من أحجام النقاط وبمعدل تكرار سريع يصل إلى 2.0 هرتز. إن إجمالي مدة النبضة البالغة 650 ميكروثانية أقل من وقت الاسترخاء الحراري لأنسجة الجلد، وبالتالي فإن الجلد يكون لديه الوقت الكافي ليبرد نفسه بين النبضات، وبالتالي حصر الحرارة في الهدف الممتص بشكل انتقائي من أجل تحقيق فاعلية سريرية أعلى وسلامة على الجلد المحيط. 19 يتم إطلاق النبضة عالية الطاقة إلى المنطقة الهدف في مدة نبضة قصيرة كهذه. إذ يكون أمام بنية الجلد المستهدفة وقت أقل لفقد الحرارة، من خلال التوصيل، إلى الجلد المحيط، وبالتالي يصل الهدف إلى درجة حرارة أعلى.

تؤدي درجة الحرارة المرتفعة في الأنسجة المستهدفة إلى تدمير أكبر للأنسجة المستهدفة لزيادة الفاعلية. وقد أجرينا دراسة منضبطة معشاة لتقييم استخدام ليزر Nd:YAG بمدة نبضة 650 ميكروثانية وطول موجي 1064 نانومتر مقارنةً بالعلاج الوهمي في علاج حب الشباب المتوسط إلى الشديد.

Table of Contents

Laser Optical Engineer

Aerolase is the fastest growing medical laser company, serving the high growth dermatology and aesthetic laser market. Nestled in the picturesque Hudson Valley in Tarrytown, NY, the location is also ideal for access to NY City and other areas of the Northeast and Mid-Atlantic U.S. We are hiring in many areas and currently seek laser optical engineers with a passion for creating new things. The company offers a friendly, team-oriented work environment and competitive compensation including salary, bonus, stock options, 401k, and health/dental/life insurance plans.

About the Team:

  • We are a diverse team of friendly, creative hard-working people with a passion for achieving our objectives
  • We are creative, hands-on and innovative with a strong orientation toward high customer satisfaction
  • We have created a very team-spirited company culture and believe it is important to have open and effective cross-functional collaboration and communications – and enjoy our work!

About the Role:

We’re looking for an enthusiastic, creative and detail-oriented problem solver to help support the production, service and repair of our unique solid-state laser devices.

Must have expertise working with assembly and/or development of small, sensitive, high precision instruments, preferably solid-state laser technology, with a high caliber technology company.  We prefer design and hands-on experience in multiple laser technologies including solid state lasers, semiconductor lasers, non-linear optical materials and devices, optical benches, and beam directors. Experience with the technical aspects of developing laser and laser-based products is strongly preferred.

Candidates should have proven ability to address complex challenges with ingenuity and innovation, and capability to work independently to manage multiple simultaneous tasks, and see all tasks to completion. Also should have the ability to work well in a collaborative multidisciplinary team environment, define and analyze system performance specifications, and ensure adherence to those specifications in the application environment.

  • Perform sensitive manual optical assembly of lasers.
  • Test, troubleshoot repair and assemble lasers, subassemblies and various components, including high-voltage laser power supplies and other electronics.
  • Support the development and implementation of test fixtures, equipment, procedures and documentation for the engineering and operations functions.
  • Support product design and development activities related to new products and product improvements.
  • Support development and maintenance of quality and regulatory documents and procedures.
  • Provide customer technical support as needed including product service, maintenance, and troubleshooting.
  • With suppliers, act as a technical and operational liaison as needed.
  • Maintain thorough, complete and accurate written records; comply fully with the company’s quality system and any regulatory requirements.
  • Follow safety rules for working with high-voltages and high-power lasers.
  • Perform other duties as completion of responsibilities necessitates or as assigned by supervisor.
  1. Minimum 5 years of experience in an engineering role involving sensitive high precision instruments, preferably involving solid state lasers.
  2. Theoretical and practical knowledge and skills of adequate policies and procedures for the control of laser hazards and high voltage hazards, using relevant protective equipment, ensuring adequate safety education and training of other personnel.
  3. Understanding of system and component design, testing and troubleshooting.
  4. Enjoy working with your hands/mechanical ability.
  5. Strong analytical and problem solving skills.
  6. Proven technical and project management skills.
  7. Experience with manufacturing within a Quality Management System (especially medical).
  8. Strong interpersonal and communication skills.
  9. Self-motivated, detail oriented and well organized. Ability to make decisions and work independently Strong work ethic and desire to help the company successful by producing a reliable product.
  10. Not afraid to ask questions and make suggestions for improvement.
  11. Be able to work under pressure due to customer demands.
  12. Strong computer skills (Windows™ software).
  13. Ability to successfully manage multiple projects and daily responsibilities. Ability to discern and appropriately communicate sensitive issues.
  14. Ability to walk, stand, bend, reach, stoop/squat, and crouch. Ability to carry heavy items.
  15. Will require working indoors and outdoors – work environment includes the office, the production areas, mechanical rooms, and customer and supplier facilities. Also includes regular contact with high-voltage equipment and laser light emissions.

BS. in Physics, Mechanical or Optical Engineering, Master’s Degree preferred

  • We are a diverse team of friendly, creative hard-working people with a passion for achieving our objectives
  • We are creative, hands-on and innovative with a strong orientation toward high customer satisfaction 
  • We have created a very team-spirited company culture and believe it is important to have open and effective cross-functional collaboration and communications – and enjoy our work!

We’re looking for an enthusiastic, creative and detail-oriented problem solver to help support the production, service and repair of our unique solid-state laser devices.

Must have expertise working with assembly and/or development of small, sensitive, high precision instruments, preferably solid-state laser technology, with a high caliber technology company.  We prefer design and hands-on experience in multiple laser technologies including solid state lasers, semiconductor lasers, non-linear optical materials and devices, optical benches, and beam directors. Experience with the technical aspects of developing laser and laser-based products is strongly preferred.  

Candidates should have proven ability to address complex challenges with ingenuity and innovation, and capability to work independently to manage multiple simultaneous tasks, and see all tasks to completion. Also should have the ability to work well in a collaborative multidisciplinary team environment, define and analyze system performance specifications, and ensure adherence to those specifications in the application environment.

  • Perform sensitive manual optical assembly of lasers.
  • Test, troubleshoot repair and assemble lasers, subassemblies and various components, including high-voltage laser power supplies and other electronics.
  • Support the development and implementation of test fixtures, equipment, procedures and documentation for the engineering and operations functions.
  • Support product design and development activities related to new products and product improvements.
  • Support development and maintenance of quality and regulatory documents and procedures.
  • Provide customer technical support as needed including product service, maintenance, and troubleshooting.
  • With suppliers, act as a technical and operational liaison as needed.
  • Maintain thorough, complete and accurate written records; comply fully with the company’s quality system and any regulatory requirements.
  • Follow safety rules for working with high-voltages and high-power lasers.
  • Perform other duties as completion of responsibilities necessitates or as assigned by supervisor.
  1. Minimum 5 years of experience in an engineering role involving sensitive high precision instruments, preferably involving solid state lasers.
  2. Theoretical and practical knowledge and skills of adequate policies and procedures for the control of laser hazards and high voltage hazards, using relevant protective equipment, ensuring adequate safety education and training of other personnel.
  3. Understanding of system and component design, testing and troubleshooting.
  4. Enjoy working with your hands/mechanical ability.
  5. Strong analytical and problem solving skills.
  6. Proven technical and project management skills.
  7. Experience with manufacturing within a Quality Management System (especially medical).
  8. Strong interpersonal and communication skills.
  9. Self-motivated, detail oriented and well organized. Ability to make decisions and work independently Strong work ethic and desire to help the company successful by producing a reliable product.
  10. Not afraid to ask questions and make suggestions for improvement.
  11. Be able to work under pressure due to customer demands.
  12. Strong computer skills (Windows™ software).
  13. Ability to successfully manage multiple projects and daily responsibilities. Ability to discern and appropriately communicate sensitive issues.
  14. Ability to walk, stand, bend, reach, stoop/squat, and crouch. Ability to carry heavy items.
  15. Will require working indoors and outdoors – work environment includes the office, the production areas, mechanical rooms, and customer and supplier facilities. Also includes regular contact with high-voltage equipment and laser light emissions.

BS. in Physics, Mechanical or Optical Engineering, Master’s Degree preferred

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Staff Accountant / Junior Accountant

Aerolase Corporation, a leading aesthetic laser innovator, seeks a Staff Accountant / Junior Accountant. Having made the Inc. 5000 list as one of the world’s fastest growing private companies as well as annual best-in-class product awards, Aerolase has transformed the market with products that provide uniquely tolerable treatments to the patients and exceptionally high ROI for the practitioners. The company offers competitive and an exciting high-growth company culture.

Duties:

• Provide support to the Controller and the management team
• Maintain day-to-day financial accounting functions, including A/P, A/R, expense tracking
• Support the month-end close process, ensuring accurate and timely monthly, quarterly, and year-end financial statements.
• Uploading annual budget and tracking actual to budget variances
• Use of financial reporting software
• Support external auditors and other required outside reporting requirements
• Participation in quarterly inventory reconciliations
• Assist team with projects such as policy creation, system implementation, client support etc.

• Some experience with and strong understanding of the monthly close process and technical accounting
• Detailed oriented, with ability to see the big picture
• Self-starter who can work independently and employ time management skills to meet deadlines.
• Knowledge of MS Excel (V-lookup, formulas, pivot tables).
• Strong interpersonal and communication skills
• Sound judgment and problem-solving skills

• Bachelor’s or master’s degree in Accounting a MUST, good understanding of GAAP
• 1-3 years’ experience in an accounting function (including internship)
• General Ledger/Operational Accounting experience
• Knowledge of Quickbooks or other reporting software a plus (more the better)
• Industry experience a plus

Senior Accountant

Aerolase Corporation, a leading aesthetic laser innovator, seeks a Senior Accountant. Having made the Inc. 5000 list as one of the world’s fastest growing private companies as well as annual best-in-class product awards, Aerolase has transformed the market with products that provide uniquely tolerable treatments to the patients and exceptionally high ROI for the practitioners. The company offers competitive and an exciting high-growth company culture.

Duties:

• Provide support to the Controller and the management team
• Own day-to-day financial accounting functions, including A/P, A/R, expense tracking
• Assist in establishing and maintaining policies & procedures in accordance with GAAP and Aerolase policy
• Key contributor to the month-end close process, ensuring accurate and timely monthly, quarterly, and year-end financial statements.
• Assist in the preparation of management reports – (cash management, various projections, month end reporting package)
• Involvement with the annual budget process
• Use of financial reporting software
• Support external auditors and other required outside reporting requirements
• Prepare and submit payroll
• Participation in quarterly inventory reconciliation to the perpetual
• Ad hoc projects

• Strong knowledge of the monthly close process and technical accounting

• Detailed oriented, with ability to see the big picture

• Experience in continuous improvement and accounting best practices

• Self-starter who can work independently and employ time management skills to meet deadlines.

• System savvy – ability to learn new financial software

• Intermediate knowledge of MS Excel (V-lookup, formulas, pivot tables).

• Global consolidations experience a plus

• Strong interpersonal and communication skills

• Sound judgment and problem-solving skills

• Bachelor’s or master’s degree in Accounting a MUST, good understanding of GAAP

• 3+ years’ experience working as a staff/senior accountant

• General Ledger/Operational Accounting experience a must

• Extensive knowledge of Quickbooks and other reporting software

• Prior involvement with system implementation

• Prior public accounting experience (any size firm) a plus

• Industry experience a plus

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